abstract：BACKGROUND:The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) is a concise health status measure for COPD. COPD patients have a variety of comorbidities, but little is known about their impact on quality of life. This study was designed to investigate comorbid factors that may contribute to high CAT...

journal_title：Respiratory research

authors： Miyazaki M,Nakamura H,Chubachi S,Sasaki M,Haraguchi M,Yoshida S,Tsuduki K,Shirahata T,Takahashi S,Minematsu N,Koh H,Nakamura M,Sakamaki F,Terashima T,Sayama K,Jones PW,Asano K,Betsuyaku T,Keio COPD Comorbidity Researc

更新日期：2014-02-06 00:00:00

abstract：BACKGROUND:Cognitive impairment has been found in chronic obstructive pulmonary disease (COPD) patients. However, the structural alteration of the brain and underlying mechanisms are poorly understood. METHODS:Thirty-seven mild-to-moderate COPD patients, forty-eight severe COPD patients, and thirty-one control subject...

journal_title：Respiratory research

authors： Li J,Fei GH

更新日期：2013-12-21 00:00:00

abstract：BACKGROUND:Heat shock protein (HSP) 47 is a collagen-specific molecular chaperone that is required for molecular maturation of various types of collagens. We recently reported that HSP47 serum levels were markedly higher in patients with acute exacerbations of idiopathic pulmonary fibrosis (IPF) when compared with pati...

journal_title：Respiratory research

authors： Kakugawa T,Yokota S,Ishimatsu Y,Hayashi T,Nakashima S,Hara S,Sakamoto N,Matsuoka Y,Kubota H,Mine M,Mukae H,Nagata K,Kohno S

更新日期：2013-11-20 00:00:00

abstract：BACKGROUND:Macrolides reduce exacerbations in patients with COPD. Their effects on health status has not been assessed as primary outcome and is less clear. This study assessed the effects of prophylactic azithromycin on cough-specific health status in COPD-patients with chronic productive cough. METHODS:In this rando...

journal_title：Respiratory research

authors： Berkhof FF,Doornewaard-ten Hertog NE,Uil SM,Kerstjens HA,van den Berg JW

更新日期：2013-11-14 00:00:00

abstract：BACKGROUND:The common cold is the most widespread viral infection in humans. Iota-carrageenan has previously shown antiviral effectiveness against cold viruses in clinical trials. This study investigated the efficacy of a carrageenan-containing nasal spray on the duration of the common cold and nasal fluid viral load i...

journal_title：Respiratory research

authors： Ludwig M,Enzenhofer E,Schneider S,Rauch M,Bodenteich A,Neumann K,Prieschl-Grassauer E,Grassauer A,Lion T,Mueller CA

更新日期：2013-11-13 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is accompanied by pulmonary inflammation and associated with extra-pulmonary manifestations, including skeletal muscle atrophy. Glycogen synthase kinase-3 (GSK-3) has been implicated in the regulation of muscle protein- and myonuclear turnover; two crucial process...

journal_title：Respiratory research

authors： Verhees KJ,Pansters NA,Baarsma HA,Remels AH,Haegens A,de Theije CC,Schols AM,Gosens R,Langen RC

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Allergic asthma is characterized by airway inflammation in response to antigen exposure, leading to airway remodeling and lung dysfunction. Epithelial-mesenchymal transition (EMT) may play a role in airway remodeling through the acquisition of a mesenchymal phenotype in airway epithelial cells. TGF-β1 is kno...

journal_title：Respiratory research

authors： Johnson JR,Nishioka M,Chakir J,Risse PA,Almaghlouth I,Bazarbashi AN,Plante S,Martin JG,Eidelman D,Hamid Q

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:During 2007-2010, the National Health and Nutrition Examination Survey (NHANES) conducted a spirometry component which obtained pre-bronchodilator pulmonary lung function data on a nationally representative sample of US adults aged 6-79 years and post-bronchodilator pulmonary lung function data for the subse...

journal_title：Respiratory research

authors： Tilert T,Dillon C,Paulose-Ram R,Hnizdo E,Doney B

更新日期：2013-10-09 00:00:00

abstract：:Transposable elements (TEs) are a class of mobile genetic elements (MGEs) that were long regarded as junk DNA, which make up approximately 45% of the genome. Although most of these elements are rendered inactive by mutations and other gene silencing mechanisms, TEs such as long interspersed nuclear elements (LINEs) ar...

journal_title：Respiratory research

authors： Sargurupremraj M,Wjst M

更新日期：2013-10-05 00:00:00

abstract：BACKGROUND:Patients with chronic obstructive pulmonary disease (COPD) can be categorized as having frequent (FE) or infrequent (IE) exacerbations depending on whether they respectively experience two or more, or one or zero exacerbations per year. Although most patients do not change category from year to year, some wi...

journal_title：Respiratory research

authors： Donaldson GC,Müllerova H,Locantore N,Hurst JR,Calverley PM,Vestbo J,Anzueto A,Wedzicha JA

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:Secondary pulmonary alveolar septal formation requires platelet derived growth factor (PDGF-A) and platelet derived growth factor receptor-alpha (PDGFRα), and their regulation influences alveolar septal areal density and thickness. Insufficient PDGFRα expression in lung fibroblasts (LF) results in failed sep...

journal_title：Respiratory research

authors： McGowan SE,McCoy DM

更新日期：2013-07-02 00:00:00

abstract：BACKGROUND:Although a large body of literature is available that describes the effects of smoking, asthma and COPD on lung function, most studies are restricted to a small age range and to one factor. As a consequence, available results are incomplete and often difficult to compare, also due to the ways the effects are...

journal_title：Respiratory research

authors： Chiappa S,Winn J,Viñuela A,Tipney H,Spector TD

更新日期：2013-05-30 00:00:00

abstract：BACKGROUND:Recent research has suggested that the Th1 and Th2 chemokine/cytokine axis contributes to the development of chronic hypersensitivity pneumonitis (HP). Acute exacerbations (AE) are significant factors in the prognosis of chronic HP. Little is known, however, about these biomarkers in association with AE in c...

journal_title：Respiratory research

authors： Miyazaki Y,Unoura K,Tateishi T,Akashi T,Takemura T,Tomita M,Inase N,Yoshizawa Y

更新日期：2013-05-25 00:00:00

abstract：BACKGROUND:Little is known about the factors associated with CT-quantified emphysema progression in heavy smokers. The objective of this study was to investigate the effect of length of smoking cessation and clinical / demographical factors on the rate of emphysema progression and FEV1-decline in male heavy smokers. M...

journal_title：Respiratory research

authors： Mohamed Hoesein FA,Zanen P,de Jong PA,van Ginneken B,Boezen HM,Groen HJ,Oudkerk M,de Koning HJ,Postma DS,Lammers JW

更新日期：2013-05-20 00:00:00

abstract：:A new international statement defines usual interstitial pneumonia (UIP) which is a histological and radiological form of idiopathic pulmonary fibrosis (IPF) more precisely than previously. In the diagnosis of IPF, either in high resolution computed tomography (HRCT) a UIP pattern must be present or alternatively spec...

journal_title：Respiratory research

authors： Kaarteenaho R

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:Tiotropium bromide is an effective therapy for COPD patients. Comparing across programs tiotropium Respimat Soft Mist inhaler was at least as efficacious as tiotropium HandiHaler, however, concerns have been raised about tiotropium's safety when given via Respimat. METHODS:The TIOSPIR trial (NCT01126437) co...

journal_title：Respiratory research

authors： Wise RA,Anzueto A,Calverley P,Dahl R,Dusser D,Pledger G,Koenen-Bergmann M,Joseph E,Cotton D,Disse B

更新日期：2013-04-02 00:00:00

abstract：BACKGROUND:Aim of this prospective study was to compare clinical and genetic findings in children with idiopathic or heritable pulmonary arterial hypertension (I/HPAH) with children affected with congenital heart defects associated PAH (CHD-APAH). METHODS:Prospectively included were 40 consecutive children with invasi...

journal_title：Respiratory research

authors： Pfarr N,Fischer C,Ehlken N,Becker-Grünig T,López-González V,Gorenflo M,Hager A,Hinderhofer K,Miera O,Nagel C,Schranz D,Grünig E

更新日期：2013-01-09 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF), the most prevalent idiopathic interstitial pneumonia, is associated with a poor prognosis. An accurate diagnosis of IPF is essential for optimal management. The recent ATS/ERS/JRS/ALAT recommendations on the diagnosis and management of IPF were developed from a systematic review of...

journal_title：Respiratory research

authors： Wells AU

更新日期：2013-01-01 00:00:00

abstract：:There is an increasing interest in the potential of exhaled biomarkers, such as volatile organic compounds (VOCs), to improve accurate diagnoses and management decisions in pulmonary diseases. The objective of this manuscript is to systematically review the current knowledge on exhaled VOCs with respect to their poten...

journal_title：Respiratory research

authors： van de Kant KD,van der Sande LJ,Jöbsis Q,van Schayck OC,Dompeling E

更新日期：2012-12-21 00:00:00

abstract：BACKGROUND:Stress of the endoplasmic reticulum (ER) leading to activation of the unfolded protein response (UPR) and alveolar epithelial cell (AEC) apoptosis may play a role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Our objectives were to determine whether circulating caspase-cleaved cytokeratin-18 (c...

journal_title：Respiratory research

authors： Cha SI,Ryerson CJ,Lee JS,Kukreja J,Barry SS,Jones KD,Elicker BM,Kim DS,Papa FR,Collard HR,Wolters PJ

更新日期：2012-11-20 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary arterial hypertension (IPAH) continues to be one of the most serious intractable diseases that might start with activation of several triggers representing the genetic susceptibility of a patient. To elucidate what essentially contributes to the onset and progression of IPAH, we investig...

journal_title：Respiratory research

authors： Shimodaira K,Okubo Y,Ochiai E,Nakayama H,Katano H,Wakayama M,Shinozaki M,Ishiwatari T,Sasai D,Tochigi N,Nemoto T,Saji T,Kamei K,Shibuya K

更新日期：2012-11-17 00:00:00

abstract：BACKGROUND:Studies have shown that epinephrine release is impaired in patients with asthma. The pregnancy of female rats (dams) with asthma promotes in their pups the differentiation of adrenal medulla chromaffin cells (AMCCs) into sympathetic neurons, mediated by nerve growth factor, which leads to a reduction in epin...

journal_title：Respiratory research

authors： Feng JT,Wu XM,Li XZ,Zou YQ,Qin L,Hu CP

更新日期：2012-11-08 00:00:00

abstract：BACKGROUND:Exposure to ozone activates innate immune function and causes neutrophilic (PMN) airway inflammation that in some individuals is robustly elevated. The interplay between immuno-inflammatory function and genomic signaling in those with heightened inflammatory responsiveness to ozone is not well understood. O...

journal_title：Respiratory research

authors： Fry RC,Rager JE,Zhou H,Zou B,Brickey JW,Ting J,Lay JC,Peden DB,Alexis NE

更新日期：2012-10-03 00:00:00

abstract：:The pulmonary innate immune system is heavily implicated in the perpetual airway inflammation and impaired host defense characterizing Chronic Obstructive Pulmonary Disease (COPD). The airways of patients suffering from COPD are infiltrated by various immune and inflammatory cells including macrophages, neutrophils, T...

journal_title：Respiratory research

authors： Haczku A

更新日期：2012-09-19 00:00:00

abstract：BACKGROUND:Evidence suggests that dendritic cells accumulate in the lungs of COPD patients and correlate with disease severity. We investigated the importance of IL-1R1 and its ligands IL-1α and β to dendritic cell accumulation and maturation in response to cigarette smoke exposure. METHODS:Mice were exposed to cigare...

journal_title：Respiratory research

authors： Botelho FM,Nikota JK,Bauer CM,Morissette MC,Iwakura Y,Kolbeck R,Finch D,Humbles AA,Stämpfli MR

更新日期：2012-09-19 00:00:00

abstract：:Asthmatics are more susceptible to influenza infections, yet mechanisms mediating this enhanced susceptibility are unknown. Influenza virus hemagglutinin (HA) protein binds to sialic acid residues on the host cells. HA requires cleavage to allow fusion of the viral HA with host cell membrane, which is mediated by host...

journal_title：Respiratory research

authors： Kesic MJ,Hernandez M,Jaspers I

更新日期：2012-09-19 00:00:00

abstract：BACKGROUND:Adherence to tuberculosis (TB) treatment is troublesome, due to long therapy duration, quick therapeutic response which allows the patient to disregard about the rest of their treatment and the lack of motivation on behalf of the patient for improved. The objective of this study was to develop and validate a...

journal_title：Respiratory research

authors： Rodrigo T,Caylà JA,Casals M,García-García JM,Caminero JA,Ruiz-Manzano J,Blanquer R,Vidal R,Altet N,Calpe JL,Penas A,Working Group on Completion of Tuberculosis Treatment in Spain.

更新日期：2012-09-02 00:00:00

abstract：BACKGROUND:25-hydroxycholesterol (25-HC) is one of the oxysterols, which are oxidized derivatives of cholesterol, and has been reported to be involved in the pathogenesis of atherosclerosis and Alzheimer's disease. In lung, the possible involvement of 25-HC in airway diseases has been revealed. In the present study, we...

journal_title：Respiratory research

authors： Koarai A,Yanagisawa S,Sugiura H,Ichikawa T,Kikuchi T,Furukawa K,Akamatsu K,Hirano T,Nakanishi M,Matsunaga K,Minakata Y,Ichinose M

更新日期：2012-07-31 00:00:00

abstract：BACKGROUND:The pathogenesis of allergic airway inflammation in asthmatic patients is complex and characterized by cellular infiltrates and activity of many cytokines and chemokines. Both the transcription factor hypoxia inducible factor-1 (HIF-1) and chemokine CCL2 have been shown to play pivotal roles in allergic airw...

journal_title：Respiratory research

authors： Baay-Guzman GJ,Bebenek IG,Zeidler M,Hernandez-Pando R,Vega MI,Garcia-Zepeda EA,Antonio-Andres G,Bonavida B,Riedl M,Kleerup E,Tashkin DP,Hankinson O,Huerta-Yepez S

更新日期：2012-07-23 00:00:00

abstract：BACKGROUND:Long-term lung allograft survival is limited by bronchiolitis obliterans syndrome (BOS). Mannose binding lectin (MBL) belongs to the innate immune system, participates in complement activation, and may predispose to graft rejection. We investigated mannose binding (MBL) during cold ischemia and in tissue sam...

journal_title：Respiratory research

authors： Budd SJ,Aris RM,Medaiyese AA,Tilley SL,Neuringer IP

更新日期：2012-07-04 00:00:00

abstract：RATIONALE:Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP alveolar macrophages are foamy, lipid-filled cells with impaired surfactant clearance and markedly r...

journal_title：Respiratory research

authors： Malur A,Kavuru MS,Marshall I,Barna BP,Huizar I,Karnekar R,Thomassen MJ

更新日期：2012-06-14 00:00:00

abstract：BACKGROUND:Recent trials demonstrate increased pneumonia risk in chronic obstructive pulmonary disease patients treated with the inhaled corticosteroid (ICS) fluticasone propionate (FP). There is limited work describing FP effects on host defenses against bacterial pneumonia. METHODS:C57BL/6 mice received daily, nose-...

journal_title：Respiratory research

authors： Patterson CM,Morrison RL,D'Souza A,Teng XS,Happel KI

更新日期：2012-05-31 00:00:00

abstract：BACKGROUND:Inhaled corticosteroids are the recommended first-line treatment for asthma but adherence to therapy is suboptimal. The objectives of this study were to compare the efficacy and safety of once-daily (OD) evening and twice-daily (BD) regimens of the novel inhaled corticosteroid fluticasone furoate (FF) in ast...

journal_title：Respiratory research

authors： Woodcock A,Bleecker ER,Busse WW,Lötvall J,Snowise NG,Frith L,Jacques L,Haumann B,Bateman ED

更新日期：2011-12-21 00:00:00

abstract：BACKGROUND:Osteoporosis is one of the systemic features of COPD. A correlation between the emphysema phenotype of COPD and reduced bone mineral density (BMD) is suggested by some studies, however, the mechanisms underlying this relationship are unclear. Experimental studies indicate that IL-1β, IL-6 and TNF-α may play ...

journal_title：Respiratory research

authors： Bai P,Sun Y,Jin J,Hou J,Li R,Zhang Q,Wang Y

更新日期：2011-12-16 00:00:00

abstract：BACKGROUND:Cigarette smoke is a major risk factor for chronic obstructive pulmonary disease (COPD), an inflammatory lung disorder. COPD is characterized by an increase in CD8(+) T cells within the central and peripheral airways. We hypothesized that the CD8(+) T cells in COPD patients have increased Toll-like receptor ...

journal_title：Respiratory research

authors： Nadigel J,Préfontaine D,Baglole CJ,Maltais F,Bourbeau J,Eidelman DH,Hamid Q

更新日期：2011-11-09 00:00:00

abstract：BACKGROUND:Neonatal mice developed neurological disease and pulmonary dysfunction after an infection with a mouse-adapted human Enterovirus 71 (EV71) strain MP4. However, the hallmark of severe human EV71 infection, pulmonary edema (PE), was not evident. METHODS:To test whether EV71-induced PE required a proinflammato...

journal_title：Respiratory research

authors： Huang SW,Lee YP,Hung YT,Lin CH,Chuang JI,Lei HY,Su IJ,Yu CK

更新日期：2011-11-06 00:00:00

abstract：:MMP28 is constitutively expressed by epithelial cells in many tissues, including the respiratory epithelium in the lung and keratinocytes in the skin. This constitutive expression suggests that MMP28 may serve a role in epithelial cell homeostasis. In an effort to determine its function in epithelial cell biology, we ...

journal_title：Respiratory research

authors： Manicone AM,Harju-Baker S,Johnston LK,Chen AJ,Parks WC

更新日期：2011-10-31 00:00:00

abstract：BACKGROUND:The coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects with both COPD and asthma. METHODS:We performed a cross-sectional study comparing subjects with COPD and asthma to subjects ...

journal_title：Respiratory research

authors： Hardin M,Silverman EK,Barr RG,Hansel NN,Schroeder JD,Make BJ,Crapo JD,Hersh CP,COPDGene Investigators.

更新日期：2011-09-27 00:00:00

abstract：BACKGROUND:In idiopathic pulmonary fibrosis loss of alveolar epithelium induces inflammation of the pulmonary tissue followed by accumulation of pathogenic myofibroblasts leading eventually to respiratory failures. In animal models inflammatory and resident cells have been demonstrated to contribute to pulmonary fibros...

journal_title：Respiratory research

authors： Blyszczuk P,Germano D,Stein S,Moch H,Matter CM,Beck-Schimmer B,Lüscher TF,Eriksson U,Kania G

更新日期：2011-09-26 00:00:00

abstract：BACKGROUND:Proteomic studies of respiratory disorders have the potential to identify protein biomarkers for diagnosis and disease monitoring. Utilisation of sensitive quantitative proteomic methods creates opportunities to determine individual patient proteomes. The aim of the current study was to determine if quantita...

journal_title：Respiratory research

authors： O'Neil SE,Sitkauskiene B,Babusyte A,Krisiukeniene A,Stravinskaite-Bieksiene K,Sakalauskas R,Sihlbom C,Ekerljung L,Carlsohn E,Lötvall J

更新日期：2011-09-22 00:00:00